Early Game (Storyline):
Early and mid game I prefer to focus on damage affixes to run through the storyline faster. I don't think anything can kill me anyway.
Most of the time I even open skill window to put new points, inventory to check new items or even Alt+Tab from the game to answer Discord messages. Totems do a great job protecting me!
But do not forget to farm for items with valuable affixes to extract them later! Loot Filter below will help you with this.
Monolith of Fate:
Early Timelines feels the same as a Storyline. You can focus on damage and run through them with a wind in your hair. So let's go straight to Empowered Timelines.
At this stage of a game I start to focus on more tanky affixes and item bases because some bosses can do a pretty big hits.
All resistances except Poison, Necrotic and Void will be capped by your passive node Protective Circle. So we need to boost these three resistances with affixes.
In a table below I will mark all places where we can put them as +% PNV Resistance. You just put there a resistance you need more.
Also one of your Turquoise Ring should have SuffixNecrotic Resistance so later we will be able to swap it for Ferebor's Persistence seamlessly.
End Game:
Just try to farm better items based on a table below. Exalted items with T6+ affixes from the Best sections would be great.
And of course for an End Game such items as Ferebor's Chisel, Ferebor's Persistence and Cradle of the Erased will make your life much-much easier!
Farming Ferebor's Set and Cradle of Erased:
While doing my Timelines I prefer to go Echoes with Rune Rewards so while I farm my items or just trying to complete Timeline I would get more Rune of Ascendance. It is very useful Rune, especially in our case. Because Ferebor's Chisel and Cradle of the Erased are common items and have a good chance to roll while using Rune of Ascendance on a normal/magic/rare dagger and shield accordingly.
So that's why I recommend to focus farm Ferebor's Persistence first. It is an Uncommon Item so it may take some time. And while you farm it you should have enough Runes to just roll both other items for this build.
Ferebor's Persistence:
Timeline to target farm: The Age of Winter ("Unique or Set Ring" echo rewards)
Rune of Ascendance chance: ≈5.22% (≈20 Runes)
Ferebor's Chisel:
Timeline to target farm: Reign of Dragons ("Unique or Set Sword or Dagger" echo rewards)
Rune of Ascendance chance: ≈14.79% (≈7 Runes)
Cradle of the Erased:
Timeline to target farm: The Black Sun ("Unique or Set Shield" echo rewards)
Rune of Ascendance chance: ≈9.55% (≈11 Runes)
Cradle of the Erased and Weaver's Will:
Shield Cradle of the Erased will have from 5 to 28 Weaver's Will points. It means that it will gain additional 5-28 tiers of affixes. I added preferable affixes in a table below. If you hit wrong affixes and you dropped one more Cradle of the Erased you may want to equip it and see what affixes it will roll, they may be better than previous.
Affix Farming:
Try to farm needed affixes from the table below. You will need them to craft your final items. I will provide a Loot Filter for you (check Loot Filter section below) and all items containing nice amount of good affixes will be highlighted with different colors. All you need is to use Rune of Shattering or Rune of Removal to extract those affixes from an item.
You can always edit Loot Filter to suite your current needs and color preferences. As an example if you already have like 50+ shards of SuffixNecrotic Resistance and you don't want to farm it anymore you may just go to Item Filter, find filters named "AFFIX FARM" (there are three of them) and remove Necrotic Resistance from a list of affixes to look for. Also you may want to modify number of affixes you want to find in any filter category, it's up to you.
For more info about Loot Filter check section Loot Filter below.