I'm planning a theoretical Low Life Variant
With the planned setup I have way less crit chance, which does significantly hurt for acheiving warcry 2 cry bonus and damage in general. I hope to gain the damage back through increseased mana and mana regen which should in turn give the exicted bolts node from gathering storm much more oomph, and it is more (multiplicative - not increased) modifier.
My planned build uses helm/belts/2nd weapon with solid increases to ward retention (Cleaver Solution gives us 40 or more int and thereby ward retention). This is critical for increasing low life build survivability.
If we need more damage and less tank, Peak of the Mountain has a huge crit chance increase and would by my first swap. Communion of the Erased could be a great swap if it has some well roled affixes, or a generic belt with the right mods. Scales of Eterra may work perfectly, I have yet to test it, but losses would also be signifcant (losing either Cleaver Solution or Tempest Maw).
If we need more tankiness and less damage, though I find this unlikely, I'd aim for having strength modifiers instead of attunement modifiers. Attunement scales damage of our primary damage source, by adding increased spell damage and increased mana (2 ways!). Strength scales tankiness by increasing our armor, and gets converted to int, increasing our ward retention (also 2 ways!).
If anyone gets to lvl 100 before me and figures out what tweaks will be necessary let me know!